Paper 1 of 3
MARC v1: An Open-Source Multi-Agent Framework for Clinical AI Reasoning and Coordination
Problem
Monolithic LLM prompting was not working as expected, and the obvious fix of manual prompt engineering is not feasible.
Approach
MARC replaces monolithic LLM prompting with deterministic multi-agent orchestration for clinical reasoning, coordinating role-specialized agents for extraction, reasoning, answer generation, and evaluation. The framework includes a Decomposer module that generates task-specific agent prompts from a plain-language description. MARC supports both API-based and local CPU-compatible deployments and is entirely configurable via YAML. The framework is designed to be model-agnostic, interpretable, and accessible to clinical domain experts without programming expertise. MARC enables stage-wise failure attribution through explicit context passing and traceable intermediate outputs.
Result
The full framework is available at https://github.com/Penn-RAIL/MARC-v1, indicating the completion of the MARC framework.
Why it matters
Clinical domain experts without programming expertise should care about this framework as it is designed to be accessible to them.
Method details
- The framework is model-agnostic
- MARC is entirely configurable via YAML
- The framework supports both API-based and local CPU-compatible deployments
Limitations
The paper does not establish any limitations.
The model could not quote the source for its claim, so nothing above has been checked against the paper. Read the abstract before trusting it.Citation check failed.
Picked because: This paper earns a slot because it presents MARC, a multi-agent framework that coordinates role-specialized agents for clinical reasoning, which is a concrete example of LLM agents and tool use.